Is food anaphylaxis a cause of antiphospholipid syndrome and thrombosis or a coincidence?

I read with great interest the article by Armentia et al. recently published in Allergologia et Immunopathologia on food anaphylaxis in antiphospholipid syndrome (APS) and thrombosis. The authors suggested that seed lipoproteins might have a potential role in the APS and related thrombosis. I think that there are certain issues, which need clarification by the authors. The first issue in need of explanation is about the randomisation of the patients. The authors mentioned that 52 patients with anaphylaxis were selected randomly from among patients with severe anaphylaxis. The number of patients with severe anaphylaxis (grade III--IV by Muller) is not clear. If the authors made this selection from among 21,879 patients, we could say that approximately, 28% of 21,879 patients may have thrombosis. This implies that development of thrombosis in patients with anaphylaxis is very high in these group patients. However, there is no clear evidence in the literature showing increased development of thrombosis in patients with anaphylaxis. Therefore the authors should give us the number of patients with severe anaphylaxis and clear information about randomisation. It seems to me that the selection of patients was made according to whether the patients have thrombosis or not. This could have led to a selection bias. The authors reported four cases with food anaphylaxis followed by thrombosis before. Were these patients included in this study? Secondly, in this study, of 52 patients with anaphylaxis, 15 (28%) had ACA IgG positivity with medium or high titre. The authors described medium or high titre as 20--80 GPL medium, >80 GPL high positive, respectively. In Table 1A, the number of patients having positive ACA IgG with medium or high titre were only seven and one in Table 1B. As a result, unlike that mentioned by the authors in the text and Tables, only eight patients had ACA IgG antibody positivity with medium or high titre (15%).